BDBM425067 4-fluoro-N-((R)-3-(2-((1R,2S)-2-(4- fluorophenyl)-1- methylcyclopropylamino)-ethylsulfonyl)-1- morpholino-1-oxopropan-2-yl)benzamide::US10519118, Example 145::US10882835, Example 17::US11230534, Example 145

SMILES C[C@]1(C[C@H]1c1ccc(F)cc1)NCCS(=O)(=O)C[C@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCOCC1

InChI Key InChIKey=FTZVADYMUISQMM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 425067   

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425067(US10519118, Example 145 | 4-fluoro-N-((R)-3-(2-((1...)
Affinity DataIC50: 1.14E+5nMAssay Description:Briefly, bulk histones, histone peptides or nucleosomes are incubated with purified human recombinant KDM1A, in the histone demethylase activity (HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425067(US10519118, Example 145 | 4-fluoro-N-((R)-3-(2-((1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assaying the inhibition of KDM1A can be determined in vitro, in cultured cells, and in animals. There are a variety of spectrophotometric methods to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425067(US10519118, Example 145 | 4-fluoro-N-((R)-3-(2-((1...)
Affinity DataIC50: 1.14E+5nMAssay Description:The KDM1A demethylase enzyme activity can obtained from mammalian cells or tissues expressing KDM1A from an endogenous or recombinant gene and purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent