BDBM424933 4-(3-(3-fluoro-4- methoxybenzyl)-4,5- dihydro-3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-12::US10842799, I-12

SMILES COc1ccc(CC2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F

InChI Key InChIKey=AEGFSHVQPCHEBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 424933   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424933(4-(3-(3-fluoro-4- methoxybenzyl)-4,5- dihydro-3H-1...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424933(4-(3-(3-fluoro-4- methoxybenzyl)-4,5- dihydro-3H-1...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent