BDBM424931 US10517872, Compound 11

SMILES OC1CNC(=O)c2nn(cc2NC(=O)c2cccc(Cn3nc(OC1)ccc3=O)n2)C1CCOCC1

InChI Key InChIKey=KMOSRUDBPHUJJQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 424931   

TargetInterleukin-1 receptor-associated kinase 1 [194-712](Human)
Merck Patent

US Patent
LigandPNGBDBM424931(US10517872, Compound 11)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712))In this assay, IRAK1 hydrolyses ATP and autophosphorylates. Measurement of IRAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM424931(US10517872, Compound 11)
Affinity DataIC50: 100nMAssay Description:IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK4 (1-460)).In this assay, IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent