BDBM424930 4-(3-isobutyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-10::US10842799, I-10

SMILES CC(C)CC1CNc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=GUPFSYKJCPJUKK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 424930   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424930(4-(3-isobutyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaa...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424930(4-(3-isobutyl-4,5-dihydro- 3H-1,2,2a1,5- tetraazaa...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent