BDBM424929 4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-9::US10842799, I-9

SMILES CN1CC(Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=SWCBDPINUHFPBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 424929   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424929(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM424929(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent