BDBM424917 US10517849, Compound 17::US11013718, Compound 17::US11547695, Compound 17

SMILES CC\C(=C/c1ccccc1)[C@@H]1C[C@H]1NC1CC2(C1)CCN(CCOC)CC2

InChI Key InChIKey=JDFPKIMKIDPSPW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 424917   

TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424917(US10517849, Compound 17 | US11013718, Compound 17 ...)
Affinity DataIC50: 100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424917(US10517849, Compound 17 | US11013718, Compound 17 ...)
Affinity DataIC50: 100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM424917(US10517849, Compound 17 | US11013718, Compound 17 ...)
Affinity DataIC50: 100nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent