BDBM423589 US10508120, Compound I-44::US10577373, Compound I-44::US11046698, Compound I-44

SMILES CNc1cc(nc2c(cnn12)C(N)=O)-c1cnn(c1)-c1ccccc1

InChI Key InChIKey=HVKUQMLZDAYUFX-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423589   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423589(US10508120, Compound I-44 | US10577373, Compound I...)
Affinity DataKd:  0.600nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423589(US10508120, Compound I-44 | US10577373, Compound I...)
Affinity DataKd:  0.600nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423589(US10508120, Compound I-44 | US10577373, Compound I...)
Affinity DataKd:  0.600nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent