BDBM423505 US10508115, Compound Ic-07

SMILES CCCCOc1nc(N)c2nc(O)n(Cc3ccc(Oc4cccc(CNCCC#N)n4)cc3)c2n1

InChI Key InChIKey=VURKPPYSMXUJLF-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 423505   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423505(US10508115, Compound Ic-07)
Affinity DataEC50:  3.57nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
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TargetInterleukin-6(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423505(US10508115, Compound Ic-07)
Affinity DataEC50:  133nMAssay Description:Compounds diluted in DMSO were transferred to individual wells of a Matrix Technologies clear, V-bottom 384-well plate using ECHO acoustic liquid han...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent