BDBM423318 US10501452, Compound 24

SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3ncccn3)cc2C1=O

InChI Key InChIKey=SKUUWDIJGSUACY-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 423318   

Target5-hydroxytryptamine receptor 2A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  7.5nMAssay Description:5-HT2A:(1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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Target5-hydroxytryptamine receptor 1A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  8.80nMAssay Description:5-HT1A: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 7(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  9.90nMAssay Description:5-HT7: (1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  11.9nMAssay Description:D2:Procedures(1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  59nMAssay Description:Displacement of [3H](+)8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi:  1.37E+3nMAssay Description:Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423318(US10501452, Compound 24)
Affinity DataKi: >2.00E+3nMAssay Description:Histamine H1: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent