BDBM423299 US10501452, Compound 5

SMILES CN1CCc2ccc(OCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2C1=O

InChI Key InChIKey=RDGPIFCCGRDXMY-UHFFFAOYSA-N

Data  22 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 423299   

Target5-hydroxytryptamine receptor 7(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced calcium flux incubated for 60 mins at 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  0.100nMAssay Description:5-HT2A:(1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  1nMAssay Description:D2:Procedures(1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  2.40nMAssay Description:5-HT1A: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 7(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  5.90nMAssay Description:5-HT7: (1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H](+)8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor stably expressed in CHO cell membranes measured after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  226nMAssay Description:Binding affinity to D3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  991nMAssay Description:Displacement of [3H]prazosin from rat cerebral cortex alpha1 adrenergic receptor measured after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to H3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to alpha2 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to D1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]pyrilamine from guinea pig cerebellum histamine H1 receptor measured after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of [3H]mesulergine from rat cerebral cortex 5HT2C receptor measured after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Nhwa Pharma.

US Patent
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi: >2.00E+3nMAssay Description:Histamine H1: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent