BDBM423218 4-methyl-2-(4- (((3S,5R)-3-methyl- 5-(4-methyl-1-oxo- 1,3- dihydroisobenzofur- an-5-yl)piperazin- 1-yl)methyl)-1H- pyrazol-1- yl)pyrimidine-5- carbonitrile::US10501449, Example 96-I

SMILES C[C@H]1CN(Cc2cnn(c2)-c2ncc(C#N)c(C)n2)C[C@H](N1)c1ccc2C(=O)OCc2c1C

InChI Key InChIKey=XLYQAXPGQVHYCI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423218   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423218(US10501449, Example 96-I | 4-methyl-2-(4- (((3S,5R...)
Affinity DataIC50: 12nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent