BDBM423192 N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyridin-5-yl]-1-[(2-{6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl}-4-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazole-4-carboxamide::US10501440, Example 21

SMILES COc1ccc(CNc2nc(C)cc3[C@@H](CCc23)NC(=O)c2cn(Cc3cnc(nc3C)N3CC4C(C3)C4(F)F)nn2)c(OC)c1

InChI Key InChIKey=TVPKTFMWCVAKPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423192   

TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423192(US10501440, Example 21 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 1.40nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
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Date in BDB:
10/12/2020
Entry Details
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