BDBM422800 US10508107, Example 6::US11312711, Example 6

SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnc(s1)-c1ccccc1

InChI Key InChIKey=VNCZMBMKODMGRG-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 422800   

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataEC50:  80nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR 1 were amplified from genomic DNA essentially as described by Lindeman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataIC50: 1.31E+3nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataEC50:  80nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR1 were amplified from genomic DNA essentially as described by Lindemann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataIC50: 1.31E+3nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataKi:  5.93E+3nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM422800(US10508107, Example 6 | US11312711, Example 6)
Affinity DataKi:  5.93E+3nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent