BDBM422151 2-butyl-1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropyridin-2- yl)benzenesulfonyl]-6- hydroxy-1,4- dihydropyrimidin-4-one::US10508104, Example 42

SMILES CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1cccc(F)n1

InChI Key InChIKey=KTHGCJXOTIFTPC-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 422151   

TargetApelin receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422151(2-butyl-1-(2,6- dimethoxyphenyl)-5-[4- (6-fluoropy...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent