BDBM422138 2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(2- methoxypyridin-3- yl)benzenesulfonyl]- 1,4-dihydropyrimidin-4- one::US10508104, Example 30

SMILES CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1cccnc1OC

InChI Key InChIKey=FPLJXJZXRQDSBL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 422138   

TargetApelin receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422138(US10508104, Example 30 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422138(US10508104, Example 30 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  0.0100nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422138(US10508104, Example 30 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422138(US10508104, Example 30 | 2-butyl-1-(2,6- dimethoxy...)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed