BDBM422110 5-(benzenesulfonyl)-2- butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-1,4- dihydropyrimidin-4-one::US10508104, Example 2

SMILES CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccccc1

InChI Key InChIKey=JIXILZKSFQODQM-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 422110   

TargetApelin receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422110(US10508104, Example 2 | 5-(benzenesulfonyl)-2- but...)
Affinity DataEC50:  5nMAssay Description:HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM422110(US10508104, Example 2 | 5-(benzenesulfonyl)-2- but...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422110(US10508104, Example 2 | 5-(benzenesulfonyl)-2- but...)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetApelin receptor(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM422110(US10508104, Example 2 | 5-(benzenesulfonyl)-2- but...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed