BDBM422073 US10508103, Embodiment 26

SMILES CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](F)C[C@H]1Cn1c(nc2cc(F)ccc12)-c1[nH]c2cc(F)ccc2c1C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C

InChI Key InChIKey=AUQURWZNRUDIPG-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 422073   

TargetBaculoviral IAP repeat-containing protein 2 [253-363](Human)
Medshine Discovery

US Patent
LigandPNGBDBM422073(US10508103, Embodiment 26)
Affinity DataIC50: 10nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBaculoviral IAP repeat-containing protein 3 [238-349](Human)
Medshine Discovery

US Patent
LigandPNGBDBM422073(US10508103, Embodiment 26)
Affinity DataIC50: 10nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Medshine Discovery

US Patent
LigandPNGBDBM422073(US10508103, Embodiment 26)
Affinity DataIC50: 10nMAssay Description:1) Affinity of compounds listed in table to cIAP1-BIR3, Ciap2-BIR3, XIAP-BIR3 was tested referring to Nikolovska-Colesks, Z. et.Al. (Analytical Bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM422073(US10508103, Embodiment 26)
Affinity DataEC50: <10nMAssay Description:First day:Dilution of Compounds: 1) tested compounds were added into DMSO to give parent liquor (10 mM); 2) reference compound Birinapant (32 μL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent