BDBM422057 5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(3,4- difluorobenzyl)imidazolidine-2,4- dione::US10508102, Example II-7

SMILES Fc1ccc(CN2C(=O)NC(Cc3c[nH]c4c(Cl)c(F)ccc34)C2=O)cc1F

InChI Key InChIKey=JSOTXQKVBHLXSF-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 422057   

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422057(US10508102, Example II-7 | 5-((7-chloro-6-fluoro-1...)
Affinity DataEC50:  121nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422057(US10508102, Example II-7 | 5-((7-chloro-6-fluoro-1...)
Affinity DataEC50:  722nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent