BDBM422045 US10508102, Compound (Ia)

SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)c(F)ccc23)C1=O

InChI Key InChIKey=BCTSGIVMFVGZSI-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 422045   

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  93.7nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent