BDBM421528 US10508086, Example 118::US10995073, Example 118

SMILES Cc1cc(Cc2nc3ccc(cc3n2-c2nnc(C)s2)S(=O)(=O)NC2(C)CC2)on1

InChI Key InChIKey=GFQGZSYLYAZPAL-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 421528   

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataEC50:  671nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataIC50: 1.50E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataEC50:  671nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataIC50: 1.50E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM421528(US10508086, Example 118 | US10995073, Example 118)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent