BDBM420015 US10472364, Compound 85::US10570167, Cpd. # 85::US11034715, Cpd. # 85::US11208414, Cpd. # 85

SMILES COc1ccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)cc1Cl

InChI Key InChIKey=JKVWDWMVPPYIOA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 420015   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 183nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 1.37E+3nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 183nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 183nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2021
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 1.37E+3nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2021
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 183nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM420015(US10472364, Compound 85 | US10570167, Cpd. # 85 | ...)
Affinity DataIC50: 1.37E+3nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent