BDBM420 3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6-(2-phenylethyl)-6-(propan-2-yl)-5,6-dihydro-2H-pyran-2-one::CHEMBL288033::Dihydropyran-2-one deriv. 25

SMILES CC(C)C1(CCc2ccccc2)CC(=O)C(Sc2cc(C)c(N)cc2C(C)(C)C)C(=O)O1

InChI Key InChIKey=TVJVEEFOSYUFLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 420   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM420(CHEMBL288033 | 3-[(4-amino-2-tert-butyl-5-methylph...)
Affinity DataIC50: 3.60nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM420(CHEMBL288033 | 3-[(4-amino-2-tert-butyl-5-methylph...)
Affinity DataIC50: 3.30nMpH: 6.2Assay Description:In vitro binding affinity against HIV protease at pH 6.2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM420(CHEMBL288033 | 3-[(4-amino-2-tert-butyl-5-methylph...)
Affinity DataIC50: 3.60nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed