BDBM419998 US10472364, Compound 67::US10570167, Cpd. # 67::US11208414, Cpd. # 67

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2cnc(s2)C(O)=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=KGZSHDGVGKZIHN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 419998   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419998(US10472364, Compound 67 | US10570167, Cpd. # 67 | ...)
Affinity DataIC50: 602nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419998(US10472364, Compound 67 | US10570167, Cpd. # 67 | ...)
Affinity DataIC50: 1.31E+3nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419998(US10472364, Compound 67 | US10570167, Cpd. # 67 | ...)
Affinity DataIC50: 602nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419998(US10472364, Compound 67 | US10570167, Cpd. # 67 | ...)
Affinity DataIC50: 602nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419998(US10472364, Compound 67 | US10570167, Cpd. # 67 | ...)
Affinity DataIC50: 1.31E+3nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent