BDBM419941 US10472364, Compound 27::US10570167, Cpd. # 27::US11034715, Cpd. # 27::US11208414, Cpd. # 27

SMILES Nc1cccc(CC(OC[C@H]2O[C@H]([C@@H](F)[C@@H]2O)n2cnc3c(N)nc(Cl)nc23)(C(O)=O)C(O)=O)c1

InChI Key InChIKey=WONRUYTWBCPPJV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 419941   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 218nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 886nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 218nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 218nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2021
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 886nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2021
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 218nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM419941(US10472364, Compound 27 | US10570167, Cpd. # 27 | ...)
Affinity DataIC50: 886nMAssay Description:The ability of compounds to inhibit endogenous, cell-bound CD73 enzyme activity was demonstrated using SK-MEL-28 cells, which express CD73 on their s...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent