BDBM4189 1,6-naphthyridin-2(1H)-one deriv. 7v::3-(2,6-Dichlorophenyl)-1-methyl-7-[[4-(4-morpholino)-phenyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(morpholin-4-yl)phenyl]amino}-1,2-dihydro-1,6-naphthyridin-2-one

SMILES Cn1c2cc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=GWHOPAUAFXUMEC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4189   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4189(3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(morpholin-4...)
Affinity DataIC50: 250nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM4189(3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(morpholin-4...)
Affinity DataIC50: 2.80E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4189(3-(2,6-dichlorophenyl)-1-methyl-7-{[4-(morpholin-4...)
Affinity DataIC50: 8.70E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2005
Entry Details Article
PubMed