BDBM418555 8-(1,3-Dimethylpyrazol-4- yl)-1-[3-fluoro-5-(trideuterio- methoxy)-4-pyridyl]-7- methoxy-3-methyl-imidazo- [4,5-c]quinolin-2-one::US10457677, Example 150

SMILES COc1cncc(F)c1-n1c2c(cnc3cc(OC)c(cc23)-c2cn(C)nc2C)n(C)c1=O

InChI Key InChIKey=WNEFOSMCGCLLJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418555   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418555(8-(1,3-Dimethylpyrazol-4- yl)-1-[3-fluoro-5-(tride...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418555(8-(1,3-Dimethylpyrazol-4- yl)-1-[3-fluoro-5-(tride...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed