BDBM418544 6-[8-(1,3-Dimethyl-1H- pyrazol-4-yl)-7-methoxy-3- methyl-2-oxo-2,3-dihydro- imidazo[4,5-c]quinolin-1-yl]- 5-fluoro-N-methyl- nicotinamid::US10457677, Example 139::US10975075, Example 139::US11608338, Example 139

SMILES CNC(=O)c1cnc(c(F)c1)-n1c2c(cnc3cc(OC)c(cc23)-c2cn(C)nc2C)n(C)c1=O

InChI Key InChIKey=MOJRPHLPRSKOFV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418544   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418544(6-[8-(1,3-Dimethyl-1H- pyrazol-4-yl)-7-methoxy-3- ...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418544(6-[8-(1,3-Dimethyl-1H- pyrazol-4-yl)-7-methoxy-3- ...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418544(6-[8-(1,3-Dimethyl-1H- pyrazol-4-yl)-7-methoxy-3- ...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent