BDBM418537 1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-methyl-8- (2-methyl-3H-benzo- imidazol-5-yl)-1,3-dihydro- imidazo[4,5-c]quinolin-2- one::US10457677, Example 132::US10975075, Example 132::US11608338, Example 132

SMILES COc1cc2ncc3n(C)c(=O)n(-c4cn(C)nc4C)c3c2cc1-c1ccc2nc(C)[nH]c2c1

InChI Key InChIKey=DPDFYHQQULBMQG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418537   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418537(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418537(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418537(1-(1,3-Dimethyl-1H-pyrazol- 4-yl)-7-methoxy-3-meth...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent