BDBM418448 8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyridin-2-yl)- 7-methoxy-3-methyl-1,3- dihydroimidazo[4,5-c] quinolin-2-one::US10457677, Example 16::US10745399, Example 16::US10975075, Example 16::US11608338, Example 16

SMILES COc1cc2ncc3n(C)c(=O)n(-c4ncccc4F)c3c2cc1-c1cn(C)nc1C

InChI Key InChIKey=UWHOOEVIOOCFKF-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 418448   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110β/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentration as n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110β/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418448(8-(1,3-Dimethyl-1H-pyrazol- 4-yl)-1-(3-fluoropyrid...)
Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent