BDBM418445 US10457677, Example 13::US10745399, Example 13::US10975075, Example 13::US11608338, Example 13

SMILES CCn1cc(cn1)-c1cc2c3n(-c4c(F)cncc4OC)c(=O)n(C)c3cnc2cc1OC

InChI Key InChIKey=QGTXTNMIEHASOC-UHFFFAOYSA-N

Data  27 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 418445   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
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TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/5/2023
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ne...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110β/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/13/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentration as n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110β/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+3nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent

LigandBDBM418445(US10457677, Example 13 | US10745399, Example 13 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL