BDBM416771 (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(2,6-difluorophenoxy)phenyl)-1H-pyrrolo[2,3-d]pyridazin-7(6H)-one::US10323037, Example 58

SMILES CC(C)(C)OC(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12

InChI Key InChIKey=OLXZTZBICUEVLT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416771   

TargetTyrosine-protein kinase BTK(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM416771(US10323037, Example 58 | (R)-1-(1-acryloylpiperidi...)
Affinity DataIC50: 10nMAssay Description:The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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