BDBM416681 (2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US10323028, Example 18(b)::US10981904, Example 18(a)

SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1

InChI Key InChIKey=MHCDCRNHIYHNIK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416681   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM416681(US10323028, Example 18(b) | (2R)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 129nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416681(US10323028, Example 18(b) | (2R)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 22.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent