BDBM416549 US10307425, Example 15::US10632122, Example 15

SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC2CCN(C)CC2)c2ncnc(N)c12

InChI Key InChIKey=AWJAAKKEYXUCFY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 416549   

TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of Washington

US Patent
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 6.10nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

US Patent
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 6.10nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

US Patent
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of chicken Src using AcEIYGEFKKK as substrate after 90 mins in presence of ATP by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 183nMAssay Description:Inhibition of recombinant FLAG-tagged PKD1 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant FLAG-tagged PKD2 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM416549(US10307425, Example 15 | US10632122, Example 15)
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant FLAG-tagged PKD3 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed