BDBM416373 8-(3,6-dihydro-2H-pyran-4-yl)-6-{[1- (2,2,2-trifluoroethyl}piperidin-4- yl]carbonyl}-6,11-dihydro-5H- pyrido[2,3-b][1,5]benzodiazepine::US10442819, Example 516

SMILES FC(F)(F)CN1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)C1=CCOCC1

InChI Key InChIKey=IPTSJZQOFHNICZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416373   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416373(US10442819, Example 516 | 8-(3,6-dihydro-2H-pyran-...)
Affinity DataIC50: 8nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
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Date in BDB:
8/24/2020
Entry Details
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