BDBM416230 6-{[trans-4-(1- methylethoxy)cyclohexyl] carbonyl}-8-(tetrahydro-2H- pyran-3-yl)-6,11-dihydro-5H- pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 374

SMILES CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)C1CCCOC1

InChI Key InChIKey=QBJGCMHCPDPGSX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416230   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416230(6-{[trans-4-(1- methylethoxy)cyclohexyl] carbonyl}...)
Affinity DataIC50: 11nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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