BDBM416203 8-[(1S,4S)-1-methyl-2-oxa-5- azabicyclo[2.2.1]hept-5-yl]-6- {[1-(2,2,2- trifluoroethyl)piperidin-4- yl]carbonyl}-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 348

SMILES C[C@@]12C[C@@H](CO1)N(C2)c1ccc2Nc3ncccc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2c1

InChI Key InChIKey=GDCPOSYERYGQOJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416203   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416203(8-[(1S,4S)-1-methyl-2-oxa-5- azabicyclo[2.2.1]hept...)
Affinity DataIC50: 12nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
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Date in BDB:
8/24/2020
Entry Details
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