BDBM416181 8-(7-methoxy-3-oxa-9- azabicyclo[3.3.1]non-9-yl)-6- {[trans-4-(1- methylethoxy)cyclohexyl]car- bonyl}-6,11-dihydro-5H- pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 326

SMILES COC1CC2COCC(C1)N2c1ccc2Nc3ncccc3CN(C(=O)[C@H]3CC[C@@H](CC3)OC(C)C)c2c1

InChI Key InChIKey=UWUZQNFUCCOWEE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416181   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416181(8-(7-methoxy-3-oxa-9- azabicyclo[3.3.1]non-9-yl)-6...)
Affinity DataIC50: 14nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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