BDBM416175 8-(2-oxa-5- azabicyclo[2.2.2]oct-5-yl)-6- {[1-(2,2,2- trifluoroethyl)piperidin-4- yl]carbonyl}-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 320::US10442819, Example 321

SMILES FC(F)(F)CN1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CC2CCC1CO2

InChI Key InChIKey=WUISXTAKLNKWOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416175   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416175(US10442819, Example 320 | 8-(2-oxa-5- azabicyclo[2...)
Affinity DataIC50: 9nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416175(US10442819, Example 320 | 8-(2-oxa-5- azabicyclo[2...)
Affinity DataIC50: 35nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent