BDBM416159 8-[(1R,5S)-8-oxa-3- azabicyclo[3.2.1]oct-3-yl]-6- {[1-(2,2,2- trifluoroethyl)piperidin-4- yl]carbonyl}-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 304

SMILES FC(F)(F)CN1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H](C1)O2

InChI Key InChIKey=CGYJNMIIGUOMMJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416159   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416159(8-[(1R,5S)-8-oxa-3- azabicyclo[3.2.1]oct-3-yl]-6- ...)
Affinity DataIC50: 13nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
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Date in BDB:
8/24/2020
Entry Details
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