BDBM415652 US10428108, Example 62::US10428108, Example 94

SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F

InChI Key InChIKey=BWMCWLVWZBKIFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 415652   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM415652(US10428108, Example 62 | US10428108, Example 94)
Affinity DataIC50: 10nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM415652(US10428108, Example 62 | US10428108, Example 94)
Affinity DataIC50: 65nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent