BDBM414883 4-Cyano-N-isopropyl-N-[1-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionyl)-piperidin-4-yl]-benzamide::US10428024, Compound A67

SMILES CC(C)N(C1CCN(CC1)C(=O)[C@@](C)(O)C(F)(F)F)C(=O)c1ccc(cc1)C#N

InChI Key InChIKey=QTWRNBIOCJZRAH-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414883   

LigandPNGBDBM414883(4-Cyano-N-isopropyl-N-[1-((R)-3,3,3-trifluoro-2-hy...)
Affinity DataIC50: 1.60E+3nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
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LigandPNGBDBM414883(4-Cyano-N-isopropyl-N-[1-((R)-3,3,3-trifluoro-2-hy...)
Affinity DataKd:  470nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent