BDBM414872 5-Fluoro-N-methyl-N-[(3R,4S)-3-methyl-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperidin-4-yl]pyridine-2-carboxamide::US10428024, Compound A53

SMILES C[C@@H]1CN(CC[C@@H]1N(C)C(=O)c1ccc(N)cn1)C(=O)[C@@](C)(O)C(F)(F)F

InChI Key InChIKey=IUTKRCYXTNJUGK-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414872   

LigandPNGBDBM414872(5-Fluoro-N-methyl-N-[(3R,4S)-3-methyl-1-[(2R)-3,3,...)
Affinity DataIC50: 410nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
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Date in BDB:
8/17/2020
Entry Details
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LigandPNGBDBM414872(5-Fluoro-N-methyl-N-[(3R,4S)-3-methyl-1-[(2R)-3,3,...)
Affinity DataKd:  51nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent