BDBM414566 US10435400, Compound Z-109

SMILES CCN(C)CCN(C)c1cc(OC)c(Nc2ncc(Cl)c(n2)-c2cnc3n(C)ccc3c2)cc1NC(=O)C=C

InChI Key InChIKey=UTXLNWHESVVNTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414566   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM414566(US10435400, Compound Z-109)
Affinity DataIC50: 6nMAssay Description:The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM414566(US10435400, Compound Z-109)
Affinity DataIC50: 28nMAssay Description:The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent