BDBM412778 N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-hydroxy-2-methylpropyl)amino]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)pyridin-2-yl]acetamide::US10399987, Example 43

SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)ccn1

InChI Key InChIKey=XTCDENUICFWZKD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412778   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412778(US10399987, Example 43 | N-[4-({2-[6-(difluorometh...)
Affinity DataIC50: 0.75nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412778(US10399987, Example 43 | N-[4-({2-[6-(difluorometh...)
Affinity DataIC50: 810nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent