BDBM412755 N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide::US10399987, Example 20

SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1

InChI Key InChIKey=HCZOMSNBQCWQJO-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 412755   

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataIC50: 940nMAssay Description:Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataIC50: 12nMAssay Description:Inhibition of TGFbetaR1 in human primary T-cells assessed as TGFbeta-stimulated PSMAD phosphorylation preincubated for 1 hr followed by TGFbeta addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataIC50: 0.670nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataIC50: 5.00E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412755(US10399987, Example 20 | N-(4-((2-(6-(trifluoromet...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed