BDBM412741 2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyridin-4-yl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 6

SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F

InChI Key InChIKey=UCTUKKCUBWWUMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412741   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412741(US10399987, Example 6 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 0.760nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412741(US10399987, Example 6 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent