BDBM412729 (3-Methyl-6-((1-methyl- 4-phenyl-1H-imidazol- 2-yl)methoxy)imidazo [1,2-b]pyridazin-2- yl)methanol::Roche-Dataset for PDE10A, Compound 121::US10399985, Example 42

SMILES Cc1c(CO)nc2ccc(OCc3nc(cn3C)-c3ccccc3)nn12

InChI Key InChIKey=VKHLKEYBYQANGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412729   

LigandPNGBDBM412729(US10399985, Example 42 | (3-Methyl-6-((1-methyl- 4...)
Affinity DataIC50: 363nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

LigandPNGBDBM412729(US10399985, Example 42 | (3-Methyl-6-((1-methyl- 4...)
Affinity DataIC50: 362nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed