BDBM412720 2,3-Dimethyl-6-((1- methyl-3-phenyl-1H- 1,2,4-triazol-5- yl)methoxy)imidazo [1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 462::US10399985, Example 33

SMILES Cc1nc2ccc(OCc3nc(nn3C)-c3ccccc3)nn2c1C

InChI Key InChIKey=OVLLQBXUWGOCIK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412720   

LigandPNGBDBM412720(US10399985, Example 33 | 2,3-Dimethyl-6-((1- methy...)
Affinity DataIC50: 51.6nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
7/27/2020
Entry Details
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LigandPNGBDBM412720(US10399985, Example 33 | 2,3-Dimethyl-6-((1- methy...)
Affinity DataIC50: 52nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed