BDBM412716 3,8-Dimethyl-6-(2-(1-methyl-4-(pyridin-2-yl)-1H-imidazol-2-yl)ethyl)-2-(trifluoromethyl)imidazo[1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 9::US10399985, Example 30

SMILES Cc1c(nc2c(C)cc(CCc3nc(cn3C)-c3ccccn3)nn12)C(F)(F)F

InChI Key InChIKey=QZZCGZAOOIPYSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412716   

LigandPNGBDBM412716(US10399985, Example 30 | 3,8-Dimethyl-6-(2-(1-meth...)
Affinity DataIC50: 3.70nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

LigandPNGBDBM412716(US10399985, Example 30 | 3,8-Dimethyl-6-(2-(1-meth...)
Affinity DataIC50: 3.72nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed