BDBM412676 US10399979, Compound 17c

SMILES COc1cc2c3cnc4[nH]ccc4c3n(C3CCCCCC3)c(=O)c2cc1OC

InChI Key InChIKey=ZWRZDGRGEBEZTR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 412676   

TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 6.59nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 0.890nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 1.09nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 2.24nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of JAK3 in human SZ4 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL2 stimulation...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed